Langerhans Cell Migration In Vivo IgE-Mediated Mast Cell Activation Induces
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چکیده
منابع مشابه
IgE-mediated mast cell activation induces Langerhans cell migration in vivo.
Langerhans cells and mast cells are both resident in large numbers in the skin and act as sentinel cells in host defense. The ability of mast cells to induce Langerhans cell migration from the skin to the draining lymph node in vivo was examined. Genetically mast cell-deficient (W/Wv) mice and control mice were sensitized with IgE Ab in the ear pinna. Seven to 14 days later, mice were challenge...
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Mast cells are the major effector cells for immediate hypersensitivity and chronic allergic reactions. These cells accumulate in mucosal tissues of allergic reactions, where immunoglobulin E (IgE) is produced locally. Here we provide evidence that, in addition to antigen that can attract IgE-bound mast cells, the type of IgE molecules that efficiently activate mast cells can promote the migrati...
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Cockcroft S. Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J Immunol 2004; 172: 4048–4058. 5 Nunomura S, Gon Y, Yoshimaru T, et al. Role of the Fc (varepsilon) RI (b)-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int Immunol 200...
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